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Synergy is inferred from the individual mechanisms, not demonstrated in combination: GHK-Cu: Cosmetically Focused Clinical Data Split-face human dermatology trials on wrinkle depth and skin density (n usually under 50 per arm) Microarray gene mapping (4,000+ genes)

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While GLP-1RA continue to be successful 17 , combinatorial approaches are being developed due to the hypothesis that additional pathway engagement will generate greater weight loss, durability of weight loss and improved tolerability 7

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