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412,413 Fecal microbiota transplantation (FMT) has also been explored as a method to reset gut microbiota composition, demonstrating improvements in metabolic parameters and neuropathic pain in preclinical studies

both alpha() and beta() isomers), isocholic acid (iCA), isodeoxycholic acid (iDCA), isochenodeoxycholic acid (iDCDA), isolithocholic acid (iLCA), 7-ketodeoxycholate, 7-epicholic acid (7-ECA), 7-oxodeoxycholic acid (7-oxoDCA), and 7-oxolithocholic acid (7-oxoLCA)

Baseline WOMAC pain score: approximately 6 out of 20 Reduction in active treatment arms: approximately 4.5 points , representing a ~76% decrease from baseline Complete freedom from knee pain at week 68: reported by roughly 1 in 8 patients (12.5%) receiving retatrutide, compared to just 4.2% in the placebo group A 76% reduction in pain scores is extraordinary approaching the range typically seen after total knee replacement surgery

FASEB J (2015) 29:33645