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We hypothesize that reduced CPT-I activity may contribute to persistent fatigue in these congenital hypothyroid patients, even after levothyroxine therapy, which alone may be insufficient to fully address the downstream metabolic consequences of TPO and TSHR gene mutations present in this cohort

Robustness The robustness studies were conducted for l-glutathione as mentioned in Table 16, n-acetyl l-cysteine as mentioned in Table 17 and Vitamin C as mentioned in Table 18 to evaluate the impact of small variations in experimental conditions on the analytical results

, Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment