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161 Overactivation of ionotropic receptors as well as mechanoporation of cellular membranes 162 lead to a massive Ca 2+ entry that mediates cellular death

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the mitochondrial glutamate oxaloacetate transaminase ( Got2 ) gene which synthesizes glutamate from aspartate and -ketoglutarate [59], and Oxoglutarate dehydrogenase (Ogdh) , a mitochondrial complex member associated with glutamate degradation [60], which regulates neurotransmitter glutamate levels and is implicated in the stress response [61]