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doi:10.1186/s12888-020-02947-9

Notably, the pro-LOX effect of estrogen was found to be inhibited following the administration of SB431542, a TGF-1 receptor inhibitor, revealing the participation of TGF- signaling in the estrogenic effect (63)

Best for: Systemic applications or multiple injury sites where broad distribution is desired Option C: Separated Sessions Sequence: BPC-157 in morning, cryotherapy in evening (or vice versa) Rationale: Eliminates potential interaction effects by separating the modalities entirely