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The FDA-approved prescribing information for semaglutide products (Ozempic, Wegovy, and Rybelsus) does not list nephrolithiasis (kidney stones) as a recognized adverse effect, and large-scale randomized controlled trials, including the SUSTAIN and STEP trial programs, have not identified kidney stones as a significant safety signal associated with semaglutide therapy

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Motus (oral) reported notable human clinical trial results for an oral supplement, and that difference - oral versus injectable - matters for many peoples preferences and lifestyles

One important factor influencing the efficacy of intra-articular drugs is their residence time within the joint