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doi: 10.1038/nri.2016.70 9 PearceELPearceEJ

Modern food environments strongly drive overeating, so while healthy habits matter, lifestyle advice alone has been insufficient to counter powerful biological and environmental forces. That is where the WHO believes medications like GLP-1s may be able to help prevent relapses

So, fenugreek flopped, but there are some spices that can legitimately boost GLP-1 in humans

This insight, which implied that a substance could be harmful at a high dose but beneficial or benign at a low one, directly prefigured the biphasic dose-responses central to hormesis and laid the groundwork for modern toxicology