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However, no definitive studies show an obvious relationship between the intake of total carbohydrates and glycemic control that can lead to type 2 diabetes (T2DM) 4,5

As Bellomo put it, The evidence is approaching the threshold where practical planning should begin in earnest, even as we await data on sustained real-world outcomes. GLP-1 medications may ultimately become an important driver of cardiometabolic health improvement, but translating clinical promise into measurable mortality experience will take years of real-world data

First, there is a lack of standardized exercise protocols across studies, with wide variability in training type, frequency, intensity, and supervision, which limits comparability and prevents the identification of optimal regimens for preserving lean mass or enhancing metabolic outcomes

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