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R min and R max were obtained by fitting the R values and the lysate-based GSH concentrations C GSH using equation: ( R R min )/( R max R )= k C GSH , in which k is a constant

An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]