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Overall, the authors suggested complex gene-environment interactions at the basis of the maternal susceptibility for the birth of a child with DS, and many others have subsequently measured or estimated biomarkers of one-carbon metabolism in MDS and control mothers, including plasma hcy, plasma or serum folate, vitamin B6 and/or vitamin B12, red blood cell (RBC) folate, and related micronutrients, searching for association with the genetic polymorphisms of folate pathway genes (Table 3)

A: In many regions, these peptides are not approved as prescription drugs for general therapeutic use, and human evidence varies by compound and indication

And BMI also doesnt factor in body fat distribution or consider other health conditions