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Key considerations remain: Adverse Effects: Gastrointestinal Effects o Nausea, vomiting, abdominal pain, bloating most common and dose-related o Constipation or diarrhea due to slowed intestinal motility o Delayed gastric emptying may worsen symptoms of gastroparesis and complicate oral medication absorption Hepatobiliary & Pancreatic Risks o Gallstones (cholelithiasis) linked to rapid weight loss and altered biliary motility o Pancreatitis rare but potentially severe

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Recommendations : Limiting or avoiding alcohol can reduce AFib frequency

As millions of Americans embrace these drugs, were witnessing a category-defining shift in how and what people eat