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A total of 46 healthy female individuals aged 4569 years were enrolled and divided into the placebo group ( n = 23) or treatment group ( n = 23), which ingested one capsule of 500 mg of hydrolyzed fish cartilage, once a day, every night for 90 days

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The relatively high systemic insulin levels counteract the lipolytic effects of the high GH levels in fat and muscle, but they do not reach adequate levels in the portal vein, so the liver remains under the control of GH, which still induces gluconeogenesis, increasing hyperglycemia [33]