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This opens the door to more reliable and effective oral-use studies, a field of research that was previously hamstrung by the compound's fragility

R.Roy-ChowdhuryN.HidvegiT.BasmaH.RennardS

Because B12 status governs homocysteine, it features in cognition research: in the randomized, placebo-controlled VITACOG trial, homocysteine-lowering B vitamins (including B12) slowed the rate of brain atrophy in older adults with mild cognitive impairment an effect concentrated in those with elevated baseline homocysteine[3]

There is no controlled human evidence on combined dosing, so this should be considered cautiously and only with professional oversight