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doi: 10.3109/10425179509074701 2 Anaya-SanchezA.FengY.BerudeJ

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Benzyl alcohol has been associated with serious adverse events and death in pediatric populations, particularly neonates, due to: Immature metabolic pathways for benzyl alcohol detoxification Accumulation of benzyl alcohol and its metabolite (benzoic acid) Gasping Syndrome characterized by metabolic acidosis, gasping respirations, CNS depression, and cardiovascular collapse For neonatal research applications, use only preservative-free Sterile Water for Injection

This necessitates frequent dosing for sustained effects but provides rapid clearance that minimizes accumulation risks