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Nutrients 12 , 1562 (2020)

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According to epidemiological studies, smoking, ill-fitting dentures, and ingested/inhaled carcinogens such as tobacco and formaldehyde are regarded as potential causative factors for oral and sinonasal mucosal melanoma ( BRAF V600E mutation and dysplastic nevi associated NRAS alterations and TERT promoter mutations ( CDKN2A , PTEN , or TP53 ( BRAF (52%), RAS (31%), NF1 (14%), and a small portion of triple wild-type ( BRAF V600 mutated CM patients in clinical management ( BRAFV600E mutations ( NRAS , NF1 , KIT, SF3B1 , and SPRED1 ( Our goals in conducting this review were to: 1) Summarize the types of mucosal melanocytic benign lesions, aiming to find possible genetic and pathological evolutional patterns from benign mucosal melanocytes lesions to malignant tumors