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Most patients apply it in the evening, but morning application works too

We also note that while we did express concerns in the CY2025 OPPS/ASC proposed rule that the CHIRP System's CTE implant may not be integral (89 FR 59294), we cannot comment further on the CHIRP System's CTE implant because the applicant for that device withdrew the application prior to the final rule and we made no final determination of the eligibility of the CHIRP System's CTE implant

Avoid vigorous shaking during reconstitution, minimize moisture exposure of the lyophilized vial, protect the vial from light, and avoid repeated freeze-thaw cycles

Ohnishi et al., 2008)