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Sarcopenia Approximately 40% of the weight reduction associated with GLP-1 RAs is derived from a lean body mass, which raises significant concerns regarding its potential negative impact on skeletal muscle functionality [110]

The 2023 international PCOS guideline confirms letrozole as first-line for ovulation induction, with metformin recommended for adults with PCOS and BMI 25 kg/m for metabolic and anthropometric outcomes

Infants, children, adolescents and women of reproductive age are also at high risk of deficiency in populations where dietary intake of B12-containing animal-derived foods is restricted

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