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Indications / Uses

Allergic reactions, such as a skin rash, are rare

Historically, such behavioral complexity was viewed as a disqualifying feature for drug development, as CNS-acting agents were associated with unpredictable neuropsychiatric liability and high regulatory barriers ( 5.4 Translational lessons from abandoned appetite peptides The historical trajectory of appetite and behavioral peptides reveals a recurring pattern: early development efforts often failed due to inadequate control over exposure, insufficient combination strategies, or overly conservative interpretations of side effects

Both are dominated by gastrointestinal adverse events nausea, constipation, diarrhea, vomiting that are mostly mild-to-moderate and dose-related