who does semaglutide not work for Experts explain why and other weight-loss drugs may everyone Who should not take semaglutide?

But GLP-1 receptor agonists exploded in popularity after researchers noticed people on the medications had lost significant amounts of weight

The STEP 8 trial (published in JAMA, 2022) enrolled 338 adults with overweight or obesity, without type 2 diabetes, and randomised them to receive either semaglutide 2.4 mg weekly or liraglutide 3.0 mg daily for 68 weeks

Change in waist circumference : The mean change in waist circumference was 18.4 cm with tirzepatide (95% CI, 19.6 to 17.2) and 13.0 cm with semaglutide (95% CI, 14.3 to 11.7)

Placebo-controlled clinical trials have shown that people who dont have diabetes lose an average of 15% from their baseline weight after taking Wegovy for 68 weeks compared to the 2.5% weight reduction in the placebo group