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Molecular Dynamics Simulation Molecular dynamics simulations were performed using GROMACS (v2023.3)

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Ketamine as a model of schizophrenia (as acute ketamine administration was associated with schizophrenia-like or psychotomimetic symptoms with large effect sizes, an increase in positive and negative symptoms [275,276]) might escape from the extraordinary complexity of extrapolation from animal models of mental disorders in general [277]

ACE also inactivates bradykinin and a number of other peptides