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Epithelial cells, ECs, and vascular smooth muscle cells (VSMCs) in multiple organ systems may be the primary targets of TMAO-induced autophagy-dependent cell death

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Similarly CCL2, CCL3 and CCL4 were linked to enhanced disease severity, being higher in patients requiring admission to intensive care in patients 36

In some embodiments, the otic pharmaceutical formulation comprises about 55% by weight of the triglycerides