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For instance, a study by Grace et al., on lambs receiving a single 2 mg subcutaneous B12 injection demonstrated significant increases in serum and liver B12 concentrations for up to 24 days compared to untreated animals (2)

Multiple-dose vials can provide more flexibility and potentially reduce cost per dose especially if you buy B12 injection bulk

Supported by an increasing number of studies these effects suggest the involvement of IGF-1 in metabolism coordination [136]

They require clinic visits, they cost more, and they don't offer a meaningful advantage over high-dose oral supplementation when absorption isn't the problem