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Acknowledgements This work was supported by the National Natural Science Foundation of China (30600661, 30872708, 30801174, 30871191 and 30900622), the Scientific Research Foundation of the Health Bureau of Hunan Province (B2007058), the Natural Science Foundation of Hunan Province (05C0163) and the Post-doctorate Scientific Research Special-purpose Project of Hunan Province (2008RS4012)

This combination works in an integrated manner to reduce appetite and increase satiety, improve glycaemic homeostasis, and promote greater energy expenditure/thermogenesis via activity at the glucagon receptor