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The trial found that participants with obesity alone who got MariTide lost up to 20% of their body weight, on average, after 52 weeks, compared with just 2.6% in the placebo group

However, it has been demonstrated that ghrelin affects bone metabolism by operating in an autocrine/paracrine mode, independent of the GH/IGF-1 axis (see Nikolopoulos et al., 2010)

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Estimated absolute differences in outcomes with SGLT-2 inhibitors and GLP-1 receptor agonists compared with placebo per 1,000 people with type 2 diabetes with moderate and very high cardiovascular risk, treated for five years