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These pharmacological agents exhibit beneficial effects on glycemic regulation, weight management, and cardiovascular outcomes, thereby establishing their essential roles in contemporary diabetes management [3-5]

For example, studies using chronic treatment with strongly lipophilic agonists such as herkinorin (Sally et al., 2010) have reported induction of negative intrinsic activity for a much broader suite of MOR antagonists than all other studies (Connor and Traynor, 2010)

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