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It is believed to engage GHRH receptors and drive pituitary GH-axis signaling in experimental systems

Neuroendocrine and stress-axis research (exploring peptide-linked signaling patterns tied to stress physiology)

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Therefore, we hypothesized that sertraline treatment in combination with RT would not only target the tumor by SHMT inhibition to enhance sensitivity of NSCLC tumors to radiation in vivo but may also release the brake on the immune system