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But it also means that taking very high doses over time, particularly of vitamins A and D, can lead to accumulation

Thus, these findings underscore the notion that translational mouse models replicate only a subset of human pathology, often readily show therapeutic effects, and lack the complexity of aged human tissues

It reduced pro-inflammatory cytokines (TNF-, IL-6, IL-1), chemokines, adhesion molecules and oxidative stress, while upregulating the expression of neurotrophic factors (neuritin and NGF) [11]