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Its defining physicochemical feature is resistance to hydrolysis at low pH, unusual for a peptide of this length and attributed to a proline-rich, conformationally constrained backbone carrying three consecutive prolines plus a fourth at position eight
J Biol Chem 282:3045265, PMID: 17724027 Ji L, Shen K, Jiang P, Morahan G, Wang Z (2011) Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells
[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Strbe S., Smoday I.M., Krezic I., Kalogjera L., Vukovic V., Zizek H., Gojkovic S., Vranes H., Barisic I., Sikiric S., et al
NAC can provide GSH as a substrate for antioxidant redox reactions
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