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The alteration in the levels of gut microbial communities following temozolomide treatment may contribute to anti-tumour activity by influencing diverse pathways, including sesquiterpenoid and triterpenoid biosynthesis, steroid and terpenoids biosynthesis, fatty acid biosynthesis and metabolism, glutathione metabolism, mineral absorption, glucose and lipid metabolism, anti-inflammatory responses, immunomodulation, and epigenetic regulation through folate production [193, 239,240,241,242,243,244,245,246]

Salvianolic acid B attenuates iopromide-induced renal tubular epithelial cell injury by inhibiting the TLR4/NF-B/NLRP3 signaling pathway

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This optimises treatment time, ensuring deeper penetration for superior results