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Most research protocols use daily or every-other-day dosing, with administration timing synchronized to the active metabolic phase of the model (early light cycle for nocturnal rodents)

A companion study by Ng and colleagues in the Journal of Molecular Endocrinology examined AOD9401 in Zucker fatty rats and reported enzyme-level effects on hormone-sensitive lipase and acetyl-CoA carboxylase consistent with the dual antilipogenic and lipolytic model developed at Monash [4]