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Blood NADs and Glutathione Metabolites are Perturbed in Various Diseases To explore whether the redox pools were modified by chronic age-related diseases, we examined blood NAD and glutathione metabolites across 11 different diseases, including various cancer types, diabetes (Type II) and neurodegenerative diseases (Parkinsons and Alzheimers)

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Rosuvastatin tablets (Crestor, AstraZeneca) were freshly dissolved in distilled water prior to each administration, following established protocols for rodent studies using oral gavage with distilled water as vehicle 36,37