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While the connection between weight reduction and pain management is notable, its essential to approach it with a comprehensive understanding of individual responses, potential interactions, and the need for a holistic approach combining medication, lifestyle adjustments, and targeted exercises

These include transient elastography (an ultrasound technique) and magnetic resonance elastography (Castera 2012)

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In this regard, using broad-spectrum PKC inhibitors, it has been shown that PKC blockade upregulated p-AMPK levels, resulting in increased levels of LC3-II formation and p62 degradation indicative of increased autophagy, which resulted in the protection against APAP hepatotoxicity (Saberi et al., 2014), thus complementing the JNK-dependent contribution of PKC in APAP hepatotoxicity described above