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NNMT is overexpressed in obese adipose tissue and is theorized to deplete SAM and NAD+ pools in adipocytes, contributing to metabolic dysfunction
They are fundamental biological processes that operate across all vascularized tissue types
Comment: While many commenters indicated that our proposed changes to the HPT requirements outlined in the CY 2026 OPPS/ASC proposed rule and/or the HPT requirements in general are burdensome, as discussed in prior sections of this final rule with comment period, only several commenters commented on our specific burden estimates for these information collections
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