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Prospective, longitudinal studies are needed to further elucidate these effects and optimize perioperative strategies in orthopedic populations

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However, while many studies have heralded the drugs benefits for metabolic issues linked to diabetes, many researchers have cautioned that there are potentially serious health risks as well, such as severe gastrointestinal problems, stomach paralysis and intestinal blockages, which some critics indicate has not been adequately disclosed on the drug labels

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