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Biochemical Research Context Cellular coenzyme involved in redox reactions Studied in mitochondrial energy metabolism models Investigated in cellular signalling pathways Explored in metabolic and ageing-related research Laboratory Investigation Areas Energy metabolism and mitochondrial pathway research Redox balance and oxidative stress models Cellular repair and metabolic signalling pathways Preclinical metabolic and mitochondrial investigations NAD+ Research Context NAD+ research continues to develop in experimental environments where investigators are studying cellular energy regulation, mitochondrial function and metabolic signalling pathways
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Mol Cells 46:133141
reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation
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