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Kinetic analysis revealed that this enhancement was due to facilitation of the formation of bridges between membrane-bound peptide molecules, demonstrating that the peptidemembrane interaction and the peptide amyloidogenesis are independent functions performed at separate molecular regions. Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

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DSIP is therefore used in laboratory models to study circadian variation in pain sensitivity, central processing of nociceptive signals, and peptide-mediated modulation of neural pathways involved in pain perception

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