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In epilepsy research, although there are several reports illustrating that enhancement of GABA-mediated inhibitory neurotransmission [139] and ion channel inhibition [140] are involved in the convulsive effects of VPA, there is also prior work supporting that HDACs serve as vital upstream regulators of molecular targets associated MoAs such as ion channel [164]

2021;610:121179 Elsevier B V

The tyrosine radicals couple together to form di-tyrosine, enabling it to scavenge oxygen radicals and inhibit linoleic acid and low-density lipoprotein oxidation

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