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During the maintenance phase (weeks 21-68), weight loss accelerates to 2-3 pounds per week on average, cumulative weight loss reaches 20-25% by week 68, body gains continue to build up, and quality of life gains become more pronounced

Some are FDA-approved for weight loss and others are approved as treatments for diabetes but can be used off-label for weight loss

These benefits make semaglutide an effective tool in managing type 2 diabetes and achieving successful medical weight loss, contributing to improved overall health outcomes for many patients

It also appears protective against central adiposity: even when associated with a high fat content (~ 42% of energy), participants following an ad libitum MD supplemented with olive oil or nuts experienced slight reductions in BW and less gain in waist circumference (WC) over a median follow-up of 4.8 years, compared with a low-fat diet group [117]