Endocare consistently and significantly decreased pain perception up to 4 hours post-treatment, whereas the control group did not show significant differences
Nat Rev Endocrinol 8 , 160171 (2012)

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Epidemiology of MASLD and the Association Between Estrogen Deficiency and MASLD in Humans The endocrine changes that characterize perimenopause usually start at approximately 45 years of age, and the median age of menopause in women from developed countries (defined by a duration of amenorrhea for 1 year) is between 50 and 52 years (33)