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59,61,65 For example, saturating the system with administered tamoxifen results in a blockade of natural estrogen action on the regulation of gonadotropins by the pituitary-hypothalamic axis and inhibition of breast cancer cell division, while inducing growth of the uterine endometrial cells

This model included fixed effects for treatment condition, period, and treatment sequence (reflecting the order in which treatments were administered), along with a random intercept for each eye

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