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The risk of gastrointestinal bleeding during acenocoumarol therapy in carriers of any of the CYP2C9 or VKORC1 variants was severely increased with exposure to weekly doses of acenocoumarol higher than 15 mg or the use of amiodarone or aspirin (62)

However, despite their significant therapeutic potential in cancer treatment, it is essential to also focus on managing immune-related adverse events (irAEs)

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In addition, pro-inflammatory cytokines , causing inflammation and muscle damage, can contribute to a decreased exercise performance