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7 Changes in the brain cytoplasmic [NAD + ]/[NADH] and [NADPH]/[NADP + ] with aging are rodent strain and species specific Through measuring the metabolome of young and aged C57BL/6J mouse brains, the lactate/pyruvate, a proxy for the cytoplasmic [NADH]/[NAD + ], was found to increase by 34%52% with aging, indicating a cytoplasmic reductive shift (Dong and Brewer, 2019), opposite to the oxidation of mitochondrial [NADH] that was found to occur in aged neurons (Dong et al., 2019a)

TMAO was found to promote the metabolism of striatal dopamine and aggravate neuroinflammation and regulate glial cell polarization [94]

Compound Overview 5-Amino-1MQ, chemically known as 5-Amino-1-methylquinolinium, is a synthetic small molecule used in biochemical research exploring enzyme-mediated metabolic pathways

Psychiatry 57 HeX.LiuW.TangF.ChenX.SongG