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Cagrilintide + retatrutide adds the amylin analog cagrilintide to reinforce satiety - useful when hunger is the main barrier

That harm can include lost sales or damage to a company's business reputation

FDA approval of Zepbound was based on results from the phase 3 SURMOUNT-1 (adults with obesity or overweight and without type 2 diabetes) and SURMOUNT-2 (adults with obesity or overweight and with type 2 diabetes) trials which both demonstrated a statistically significant reduction in body weight compared to those who received placebo after 72 weeks of treatment

Individual tolerability depends on baseline metabolic state, dosing speed, and genetic factors affecting peptide-hormone sensitivity