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Growth differentiation factor 8 (GDF8)/myostatin, acting via ActRIIA/B receptors, is the best-characterized negative regulator of muscle mass, leading to therapeutic efforts to augment muscle growth by blocking GDF8 or ActRIIA/B

Patients with visceral obesity demonstrate increased LV myocardial mass, concentric LV hypertrophy and diastolic dysfunction

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The same study showed increased levels of glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide, and peptide YY (PYY) in POTS after oral glucose tolerance test, and there was a time-dependent correlation between levels of GIP and decreased stroke volume/increased HR after tilt test