what is microdosing a glp-1 GLP-1s: Risks & Considerations Should Everyone be Microdosing GLP-1s?

AGEs can crosslink collagen, reduce tissue flexibility and interfere with normal protein turnover

Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intracellular side of transmembrane helix 6, resulting in G-protein interaction and activation 2,3,4,5,6

"Food-Drug Interactions: The Case of Glutathione." Nutrients, 11(8), 1820

Theyve been on the market for less than half a decade but they already take up over a third of total industrywide DTC spending