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Without getting too nerdy, creatine is needed during exercise to supply ATP, the body's primary form of energy

Common signs of a B12 deficiency include: Fatigue Weakness Pale skin Poor coordination Heart palpitations Loss of appetite Unexplained weight loss A B12 deficiency can also contribute to mental health issues like depression and cognitive issues like confusion and poor memory

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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)