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However, it is important to note that retatrutide remains an investigational drug it has not yet received regulatory approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for routine clinical use in the UK
The topline results from the ESSENCE trial of semaglutide showed that a once-weekly 2.4mg dose of the drug was better than placebo at resolving MASH and improving liver fibrosis, meeting its primary efficacy objectives
Risk of hepatic and extrahepatic outcomes associated with metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction and alcohol-associated steatotic liver disease: a systematic review and meta-analysis
Prospective randomized controlled trials should investigate the impact of vitamin D supplementation in combination with GLP-1 receptor agonists, with a focus on doseresponse relationships and long-term metabolic outcomes
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