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Key considerations if a patient discloses combined use include: Gastrointestinal effects : Both agents may independently cause nausea, vomiting, or appetite suppression

TLR4 expression is increased in patients with GERD, triggering an inflammatory response involved in the further development of GERD.TLR4 expression in normal squamous epithelial samples is mainly confined to the basal layer of the squamous epithelium, which routinely may not come into contact with PAMPs expressed by the esophageal microbiota, and reflux increases TLR4 expression (49)

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d ) Representative DCE-MRI scans from 3 recovered, Long COVID and brain fog participants