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in humans, microbial enzymes may degrade TCM metabolites before absorption, creating non-responders (Zimmermann et al., 2019). 6.6.2 Viable translational paths: to bridge this gap, we propose integrating the following strategies Clinical and Preclinical Alignment: Prioritize comparative functional indicators (e.g., targeted metabolite quantification, barrier markers like Zonulin/LPS) over mere taxonomic lists to enhance the testability of functional output in humans

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