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Muscle and heart disease: including muscle weakness, cardiomyopathy (myocardial hypertrophy or dilation), and arrhythmias.Nervous system effects: may manifest as brain damage, seizures, intellectual disability, ataxia, etc

These neurotrophic factors play a crucial role in neuronal growth, survival, and differentiation, and their downregulation is implicated in depression

Translating the signal into proportionate action Persistent, unexplained elevation can justify further evaluation or a search for occult disease when the history, examination, CBC, liver tests, renal function, or other findings support it